Transcriptome microarray technology and methods of using the same
OwnerPaul Harkin, Patrick Johnston +1inventors
InventorsPaul Harkin, Patrick Johnston, Karl Mulligan
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Abstract
Arrays containing a transcriptome of a diseased tissue and methods of using the arrays for diagnosis, prognosis, screening, and identification of disease are provided herein. The transcriptome arrays from diseased tissue are useful for diagnosis of a disease by analysis of the genetic profile of a tissue sample specific to a disease state. The genetic profiles are then correlated with data on the effectiveness of specific therapeutic agents. Correlating expression profiles to the effectiveness of therapeutic agents provides a way to screen and select further patients predicted to respond to those therapeutic agents, thereby minimizing needless exposure to ineffective therapy.
Claims20
An array comprising a transcriptome from a diseased tissue.
A method for diagnosing a pathological condition in a patient comprising:
- a) contacting an array comprising a transcriptome from a diseased tissue with a transcript-specific element from a biological sample from the patient;
- and
- b) detecting hybridization of a transcript-specific element with the array;
- wherein detection of hybridization indicates a diagnosis of the pathological condition.
A prognostic method for determining whether a patient who has been diagnosed with a disease or disorder will recover or relapse after preliminary medical intervention comprising:
- a) contacting an array comprising a transcriptome from a diseased tissue with a transcript-specific element from a biological sample from the patient;
- and
- b) detecting hybridization of a transcript-specific element with the array;
- wherein detection of hybridization indicates prognosis for recovery of the pathological condition.
A method for determining responsiveness of a patient afflicted with a pathological condition to a therapeutic agent for treatment of the pathological condition comprising:
- a) contacting an array comprising a transcriptome from a diseased tissue with a transcript-specific element from a biological sample from the patient;
- and
- b) detecting hybridization of a transcript-specific element with the array;
- wherein detection of hybridization indicates responsiveness of the pathological condition of the patient to treatment by the therapeutic agent.
Dependencies are inferred from the claim text.