Treatment of cancer and compositions
OwnerRichard Essnerinventor
Life of this patent
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Abstract
The invention discloses a method of identifying a gene associated with stage III primary cancer or lymph node metastasis. The genes so identified include CAV1, CST3, LIMK1, MMP2, MMP15, VEGF, ETV4, MMP9, PIK3C2B, and SERPIN1. Also disclosed are methods for diagnosis, prognosis, and treatment of cancer. The invention further discloses compositions for preventing and treating diseases.
Claims62
A method of identifying a gene associated with stage III primary cancer or lymph node metastasis, comprising:
- identifying a metastasis-associated gene differentially expressed in stage I or II primary cancer than in stage III primary cancer;
- analyzing the expression of the gene in the stage I or II primary cancer and the stage III primary cancer or lymph node metastasis;
- and
- relating the expression of the gene to the stage III primary cancer, the lymph node metastasis, or a combination thereof.
A method of determining whether a subject is likely to be suffering from stage III cancer, comprising:
- providing a test sample from a subject;
- and
- detecting the expression of one or more genes selected from a first group consisting of CAV1, CST3, LIMK1, MMP2, MMP15, VEGF, ETV4, MMP9, PIK3C2B, and SERPIN1 in the sample,
- wherein the expression of one or more genes selected from a second group consisting of CAV1, CST3, LIMK1, MMP2, MMP15, and VEGF in the sample, if higher than its respective control value, the expression of one or more genes selected from a third group consisting of ETV4, MMP9, PIK3C2B, and SERPIN1 in the sample, if lower than its respective control value, or a combination thereof, indicates that the subject is likely to be suffering from stage III cancer.
A method of staging cancer, comprising:
- providing a test sample from a subject;
- and
- detecting the expression of one or more genes selected from a first group consisting of CAV1, LIMK1, MMP15, and VEGF in the sample,
- wherein the level of the expression of the one or more genes indicates that the subject is likely to be suffering from stage I or II primary cancer, stage III primary cancer with micrometastasis, stage III primary cancer with macrometastasis, or lymph node metastasis.
A method of identifying a candidate compound for treating stage III cancer, comprising:
- providing a stage III cancer cell that expresses one or more genes selected from a first group consisting of CAV1, CST3, LIMK1, MMP2, MMP15, VEGF, ETV4, MMP9, PIK3C2B, and SERPIN1;
- contacting the cell with a test compound;
- and
- detecting the expression of the one or more genes selected from the first group in the cell,
- wherein the expression of one or more genes selected from a second group consisting of CAV1, CST3, LIMK1, MMP2, MMP15, and VEGF, if lower than its respective control value, the expression of one or more genes selected from a third group consisting of ETV4, MMP9, PIK3C2B, and SERPIN1, if higher than its respective control value, or a combination thereof, indicates that the test compound is a candidate for treating stage III cancer.
A method of identifying a candidate compound for treating cancer, comprising:
- providing a system that expresses one or more genes selected from a first group consisting of CAV1, CST3, MMP15, ETV4, MMP9, PIK3C2B, and SERPIN1;
- contacting the system with a test compound;
- and
- detecting the expression of the one or more genes selected from the first group in the system,
- wherein the expression of one or more genes selected from a second group consisting of CAV1, CST3, and MMP15, if lower than its respective control value, the expression of one or more genes selected from a third group consisting of ETV4, MMP9, PIK3C2B, and SERPIN1, if higher than its respective control value, or a combination thereof, indicates that the test compound is a candidate for treating cancer.
A method of treating stage III cancer, comprising:
- identifying a subject suffering from stage III cancer;
- and
- administering to the subject one or more compounds that decrease the expression of one or more genes selected from a first group consisting of CAV1, CST3, LIMK1, MMP2, MMP15, and VEGF, increase the expression of one or more genes selected from a second group consisting of ETV4, MMP9, PIK3C2B, and SERPIN1, or a combination thereof, in the subject.
A method of treating cancer, comprising:
- identifying a subject suffering from cancer;
- and
- administering to the subject one or more compounds selected from a group consisting of a first compound that inhibits the expression of CAV1, a second compound that inhibits the expression of CST3, a third compound that inhibits the expression of MMP15, a fourth compound that enhances the expression of ETV4, a fifth compound that enhances the expression of MMP9, a sixth compound that enhances the expression of PIK3C2B, and a seventh compound that enhances the expression of SERPIN1.
A method of treating cancer, comprising:
- identifying a subject suffering from cancer;
- and
- administering to the subject a combination of at least two compounds selected from the group consisting of a first compound that inhibits the expression of CAV1, a second compound that inhibits the expression of CST3, a third compound that inhibits the expression of LIMK1, a fourth compound that inhibits the expression of MMP2, a fifth compound that inhibits the expression of MMP15, a sixth compound that inhibits the expression of VEGF, a seventh compound that enhances the expression of ETV4, an eighth compound that enhances the expression of MMP9, a ninth compound that enhances the expression of PIK3C2B, and a tenth compound that enhances the expression of SERPIN1,
- wherein the combination is not a first combination of the third and fourth compounds, a second combination of the third and sixth compounds, a third combination of the fourth and sixth compounds, or a fourth combination of the third, fourth, and sixth compounds.
A composition, comprising one or more therapeutic compounds and a transdermal drug delivery agent.
A composition, comprising a combination of at least two compounds selected from the group consisting of a first compound that inhibits the expression of CAV1, a second compound that inhibits the expression of CST3, a third compound that inhibits the expression of LIMK1, a fourth compound that inhibits the expression of MMP2, a fifth compound that inhibits the expression of MMP15, a sixth compound that inhibits the expression of VEGF, a seventh compound that enhances the expression of ETV4, an eighth compound that enhances the expression of MMP9, a ninth compound that enhances the expression of PIK3C2B, and a tenth compound that enhances the expression of SERPIN1, wherein the combination is not a first combination of the third and fourth compounds, a second combination of the third and sixth compounds, a third combination of the fourth and sixth compounds, or a fourth combination of the third, fourth, and sixth compounds.
A kit, consisting of a combination of at least two agents selected from the group consisting of a first agent for detecting the expression of CAV1, a second agent for detecting the expression of CST3, a third agent for detecting the expression of LIMK1, a fourth agent for detecting the expression of MMP2, a fifth agent for detecting the expression of MMP15, a sixth agent for detecting the expression of VEGF, a seventh agent for detecting the expression of ETV4, an eighth agent for detecting the expression of MMP9, a ninth agent for detecting the expression of PIK3C2B, and a tenth agent for detecting the expression of SERPIN1, wherein the combination is not a first combination of the third and fourth agents, a second combination of the third and sixth agents, a third combination of the fourth and sixth agents, or a fourth combination of the third, fourth, and sixth agents.
Dependencies are inferred from the claim text.