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US 2006/0134656 A1Published application
Reduction of non-specific adsorption of biological agents on surfaces
OwnerRobert Hamers, Tami Clare +2inventors
InventorsRobert Hamers, Tami Clare, Nicholas Abbott, Brian Clare
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Abstract
The present invention relates to surface-modified substrates that demonstrate reduced non-specific adsorption of biological agents. The substrates are silicon or carbon substrates having ethylene glycol oligomers covalently bound to at least one substrate surface. The substrates may be used in sensor devices, such as biochips, and in implantable medical devices in order to reduce the non-specific binding of biological agents.
Claims31
A surface-modified substrate comprising:
- a. a silicon or carbon substrate having a surface;
- and
- b. a layer comprising hydroxyl-terminated ethylene glycol oligomers covalently bound to the surface.
A sensor device comprising:
- a. a silicon or carbon substrate having a surface;
- and
- b. a layer of molecules covalently bound to the surface, the layer at least partially comprising a random distribution of ethylene glycol oligomers and probe molecules.
A surface-modified substrate comprising:
- a. a carbon substrate having a surface;
- and
- b. a layer comprising ethylene glycol oligomers covalently bound to the surface.
Dependencies are inferred from the claim text.