Notch1 variants associated with cardiovascular disease
AssigneeBoard of Regents, The University of Texas System
InventorsDeepak Srivastava, Vidu Garg
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Abstract
Human individuals at increased risk for vascular pathology are identified by determining whether the individuals' genome comprises a Notch1 allele predetermined to be associated with an increased risk for vascular pathology. Notch1 alleles are identified as being associated with increased risk for vascular pathology by detecting the presence of a same Notch allele in a plurality of persons with increased risk for vascular pathology.
Claims20
A method of identifying a human individual for increased risk for vascular pathology the method comprising the step of:
- (a) determining whether the individual's genome comprises a Notch1 allele predetermined to be associated with an increased risk for vascular pathology, wherein the presence of the allele identifies the individual as at increased risk for vascular pathology.
A method of identifying a Notch1 allele as being associated with increased risk for vascular pathology, the method comprising the step of:
- (a) detecting the presence of a same Notch allele in a plurality of persons with increased risk for vascular pathology, wherein the selective presence of the allele in these persons identifies the allele as being associated with increased risk of vascular pathology.
An isolated variant human Notch1 polypeptide that differs from wild type human Notch1 polypeptide by a single amino acid substitution of R1280H.
Dependencies are inferred from the claim text.