Method for determining susceptibility to schizophrenia
OwnerMichel Maziade, Chantal Merette +1inventors
InventorsMichel Maziade, Chantal Merette, Marc-Andre Roy
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Abstract
The present invention relates to methods for identifying the susceptibility or predisposition of an individual to schizophrenia SZ) or to clusters of symptoms associated thereof. Particularly, the tests can be performed before or after the disorders appear. More particularly, the present invention relates to the determination of epistatic effect of at least two genotype related loci. In addition, the invention provides tests for the classification of different subtypes predicting severity of illness of patients affected by or predisposed to SZ or associated clusters of symptoms.
Claims17
A method for determining susceptibility of an individual to develop at least one of SZ or associated clusters of symptoms thereof before the illness appears comprising;
- a) characterizing in an individual a genotype markers combination of at least one genotype markers located in genotype region 6p22.3 and at least one genotype marker located in genotype region 18q2 1.1;
- and
- b) comparing genotype markers of said individual of step a) with genotype markers of a patient diagnosed for SZ or associated clusters of symptoms thereof located in genotype regions 6p22.3 and 18q21.1, wherein detecting presence of genotype markers of said patient diagnosed for SZ or associated clusters of symptoms thereof in genotype regions 6p22.3 and 18q21.1 of said individual is representative of the susceptibility of to develop at least one of SZ or associated clusters of symptoms thereof.
A method for diagnosing illness or predicting severity of illness of at least one of SZ or associated clusters of symptoms thereof of an individual comprising;
- a). characterizing in an individual a genotype markers combination of at least one genotype markers located in genotype region 6p22.3 and at least one genotype marker located in genotype region 18q21.1;
- and
- b) comparing genotype markers of said individual of step a) with genotype markers of a patient diagnosed for SZ or associated clusters of symptoms thereof located in genotype regions 6p22.3 and 18q21.1, wherein detecting presence of genotype markers of said patient diagnosed for SZ or associated clusters of symptoms thereof in genotype regions 6p22.3 and 18q21.1 of said individual is representative of the presence of illness or the severity of illness of at least one of SZ or associated clusters of symptoms thereof of said patient.
Dependencies are inferred from the claim text.