Marker gene
AssigneeImmunoClin Limited Osaka Industrial Promotion Organization
InventorsMasaaki Miyazawa, Mario Clerici
Life of this patent
Estimating the term…
Abstract
A method of determining a predisposition to infection, especially infection with HIV, together with therapy for the infection is described.
Claims61
A method of determining a predisposition to infection, the method comprising the steps of obtaining a DNA bearing sample from a subject, and assaying the sample to identify the alleles present at at least one of the microsatellite loci D22S929, D22S277, D22S264, D22S423 & D22S418 or D22S272, wherein the presence of particular alleles at microsatellite loci D22S929, D22S277, D22S264, D22S423 & D22S418 or D22S272 is indicative of a resistance to infection.
(canceled)
A kit for the diagnosis of a predisposition to infection, the kit comprising reagents for determination of genotype at at least one of the microsatellite loci D22S929, D22S277, D22S264, D22S423 & D22S418 or D22S272 or a nucleic acid complementary thereto, fragments, polymorphisms, splice variants or homologues thereof.
(canceled)
A vector bearing ea chromosomal fragment that comprises at least one of the microsatellite loci D22S929, D22S277, D22S264, D22S423 & D22S418 or D22S272 or a nucleic acid complementary thereto, or fragments, polymorphisms, splice variants or homologues thereof.
18-21. (canceled)
A peptide, polypeptide, protein or glycosylation, sulphonation, acetylation, or other post-translational derivative, functional derivative, homologue or fragment thereof comprising an amino acid sequence encoded by a gene located in a chromosomal segment adjacent to microsatellite loci D22S929, D22S277, D22S264, D22S423 & D22S418 or D22S272, complementary nucleic acids or fragments, polymorphisms, splice variants, complementary nucleic acids or homologues of said gene.
23-25. (canceled)
(canceled)
(canceled)
(canceled)
32-34. (canceled)
(canceled)
(canceled)
A vaccine comprising at least one naked DNA sequence according to any one of SEQ ID NOS:1 to 10.
A vaccine comprising a DNA sequences comprising a microsatellite loci D22S929, D22S277, D22S264, D22S423 & D22S418 or D22S272, or fragments, polymorphisms, splice variants, complementary nucleic acids or homologues of said DNA sequence.
41-43. (canceled)
A chip or assay plate comprising DNA encoding the microsatellite loci D22S929, D22S277, D22S264, D22S423 & D22S418 or D22S272, or fragments, polymorphisms, splice variants, complementary nucleic acids or homologues of DNA.
(canceled)
(canceled)
A method for producing an immunoglobulin A which provides resistance to infection or possesses antiviral activity comprising contacting a cell with microsatellite loci D22S929, D22S277, D22S264, D22S423 & D22S418 or D22S272, complementary nucleic acids or fragments, polymorphisms, splice variants or homologues thereof to thereby produce an immunoglobulin A which provides resistance to infection or possesses antiviral activity.
(canceled)
(canceled)
(canceled)
A nucleic acid encoding a locus controlling production of neutralising antibodies to HIV.
(canceled)
(canceled)
Dependencies are inferred from the claim text.