Compositions and methods for treating niddm and other conditions and disorders associated with ampk regulation
AssigneeVDF Futureceuticals, Inc.
InventorsDusan Miljkovic, Zbigniew Pietrzkowski
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Abstract
Compositions and methods are provided to increase glucose uptake in a cell as well as to treat a patient suffering from a condition or disorder associated with AMPK regulation. Particularly contemplated compositions include a compound that is isolated from a plant that has AICAR-like activity. In another aspect of the invention, contemplated compositions comprise a non-insulin compound that has AICAR-like activity and activates AMPK in a cell.
Claims17
A method for activating 5′-monophosphate-activated protein kinase (AMPK) in a patient in need thereof, wherein the method comprises administering to said patient a composition comprising a therapeutically effective amount of a compound that activates AMPK, wherein the compound that activates AMPK has the structure of a compound purified from an extract of ground barley malt.
A method for treating a patient suffering from a condition or disorder associated with AMPK regulation, wherein the method comprises administering to said patient a composition comprising a therapeutically effective amount of a compound that activates AMPK, wherein the compound that activates AMPK has the structure of a compound purified from an extract of ground barley malt.
A process for purifying from an extract of ground barley malt a composition comprising a compound that activates AMPK, wherein the process comprises:
- (1) fractionating the extract of ground barley malt by ion exchange chromatography into protein fractions;
- (2) collecting one or more protein factions;
- and
- (3) removing protein from the protein fractions by molecular sieving chromatography to result in a purified compound that activates AMPK.
Dependencies are inferred from the claim text.