Process for producing microparticles
AssigneeSanten Pharmaceutical Co., Ltd.
InventorKazuhito Yamada
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Abstract
An object of the present invention is to provide a solvent which is able to produce microparticles where content of the drug is still high and no initial burst takes place even when a drug having a low solubility in a halogenated hydrocarbon solvent is used. The present invention provides a process for production by a solvent-evaporation microencapsulation method, of microparticles which are composed of biodegradable polymer and contain a drug having a low solubility in a halogenated hydrocarbon, which is characterized in that the drug and the biodegradable polymer are dissolved in a mixed solvent comprising a first solvent: halogenated hydrocarbon, and a second solvent: a water-immiscible organic solvent in which solubility of the above-mentioned drug is 0.3% (w/v) or more.
Claims10
A process for production by a solvent-evaporation microencapsulation method, of microparticles which are composed of biodegradable polymer and contain a drug having a low solubility in a halogenated hydrocarbon, which is characterized in that the drug and the biodegradable polymer are dissolved in a mixed solvent comprising
- a first solvent:
- halogenated hydrocarbon, and
- a second solvent:
- a water-immiscible organic solvent in which solubility of the above-mentioned drug is 0.3% (w/v) or more.
A process for production of microparticles in which betamethasone and a biodegradable polymer are dissolved in a solvent comprising a halogenated hydrocarbon and phenylalkyl alcohol to form an oily phase, the oily phase is mixed with an aqueous phase to form an o/w type emulsion and then the above-mentioned solvents are removed to produce the microparticles.
Dependencies are inferred from the claim text.