Adhesive composition for carrying therapeutic agents as delivery vehicle on coatings applied to vascular grafts
AssigneeUniversity of Tennessee Research Foundation
InventorsOmran Abul-Khoudoud, Catherine Cagiannos, Waldemar DeRijk, Timothy Fabian, Lisa Jennings
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Abstract
Water-soluble polymeric adhesive compositions and their use as delivery vehicles for carrying therapeutic agents on implantable devices, such as vascular grafts, are disclosed. Use of drug-coated vascular grafts is demonstrated for delivery of the therapeutic agents in vivo, thereby inhibiting restenosis or neointimal hyperplasia of the vascular graft and inhibiting infection at the vascular graft site. Methods of forming the adhesive and making the coated vascular grafts are also disclosed.
Claims37
A composition comprising:
- one or more volatile solvents;
- a first hydrophilic monomer component;
- and
- a second hydrophilic monomer component that is different from the first hydrophilic monomer component,
- wherein the first and second hydrophilic monomer components form a water-soluble polymerization product upon contact.
The method according to claim 24, wherein the extended release occurs in a period of about 2 days to about 6 months.
Dependencies are inferred from the claim text.