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US 2006/0134210 A1Published application
Solid dosage form comprising proton pump inhibitor and suspension made thereof
AssigneeAstraZeneca AB
InventorsEva Persson, Eva Trofast
Life of this patent
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Abstract
A solid, rapidly gelling oral pharmaceutical dosage form, as well as an aqueous formulation prepared thereof, comprising a) an acid sensitive proton pump inhibitor as active ingredient distributed in a multitude of enteric coated pellets, and b) a suspension modifying granulate. Furthermore, the invention relates to an improved process for the manufacture and the use of such formulation in medical treatment, including prevention of gastrointestinal disorders in humans.
Claims32
A solid oral pharmaceutical dosage form comprising:
- (a) a multitude of enteric coated pellets, wherein each enteric coated pellet comprises an acid sensitive proton pump inhibitor, and (b) a suspension modifying granulate comprising a rapidly dissolving diluent, a gelling agent which is a xanthan gum, an acidic pH-regulating agent, a binder, and optionally, a disintegrant, wherein the dosage form is a rapidly-gelling granulate mixture, with the proviso that the granulate is free from bicarbonate and carbonate salts.
Dependencies are inferred from the claim text.