Controlled release and taste masking oral pharmaceutical composition
AssigneeCosmo Technologies Limited
InventorsRoberto Villa, Massimo Pedrani, Mauro Ajani, Lorenzo Fossati
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Abstract
Controlled release and taste masking compositions containing one or more active principles inglobated in a three-component matrix structure, i.e. a structure formed by successive amphiphilic, lipophilic or inert matrices and finally inglobated or dispersed in hydrophilic matrices. The use of a plurality of systems for the control of the dissolution of the active ingredient modulates the dissolution rate of the active ingredient in aqueous and/or biological fluids, thereby controlling the release kinetics in the gastrointestinal tract.
Claims16
Controlled release and taste-masking oral pharmaceutical compositions containing budesonide as active ingredient comprising:
- a) a matrix consisting of lipophilic compounds with melting point lower than 90 C in which the active ingredient is at least partially inglobated;
- b) an amphiphilic matrix;
- c) an outer hydrophilic matrix in which the lipophilic matrix and the amphiphilic matrix are dispersed;
- d) optionally other excipients.
Dependencies are inferred from the claim text.