Dosage form containing diphenhydramine and another drug

A bi-layered tablet which comprises a first layer and a second layer, the first layer comprising a first drug which is at least one of diphenhydramine and a pharmaceutically acceptable salt thereof, and the second layer comprising at least one second drug which is selected from decongestants, antitussives, expectorants, mucus thinning drugs and analgesics, wherein the bi-layered tablet provides a plasma concentration within a therapeutic range of the at least one second drug over a period which is coextensive with at least about 60% of a period over which the bi-layered tablet provides a plasma concentration within a therapeutic range of the first drug.

A multi-layered tablet which comprises at least a first layer and a second layer, wherein the first layer comprises at least one of diphenhydramine and a pharmaceutically acceptable salt thereof and the second layer is a controlled release layer and comprises at least one drug which is selected from decongestants, antitussives, expectorants, mucus thinning drugs and analgesics.

A liquid dosage form which comprises (a) at least one of diphenhydramine and a pharmaceutically acceptable salt thereof and (b) at least one drug which is selected from decongestants, expectorants, mucus thinning drugs, antitussives and analgesics, wherein the liquid dosage form provides a plasma concentration within a therapeutic range of component (b) over a period which is coextensive with at least about 60% of a period over which the liquid dosage form provides a plasma concentration within a therapeutic range of component (a).

A pharmaceutical dosage form which comprises (a) a first drug which is diphenhydramine or a pharmaceutically acceptable salt thereof and has a first plasma half-life and (b) at least one second drug which is selected from decongestants, antitussives, expectorants, mucus thinning drugs and analgesics and has a second plasma half-life which differs from the first plasma half-life by at least about 1 hour, wherein the dosage form provides a plasma concentration within a therapeutic range of the at least one second drug over a period which is coextensive with at least about 70% of a period over which the dosage form provides a plasma concentration within a therapeutic range of the first drug.

A pharmaceutical dosage form which comprises (a) at least one of diphenhydramine and a pharmaceutically acceptable salt thereof in a first form or layer and (b) at least one of diphenhydramine and a pharmaceutically acceptable salt thereof in a second form or layer which is different from the first form or layer, wherein the dosage form releases the diphenhydramine (b) at least one of over a different period and at a different rate than the diphenhydramine (a).