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US 2006/0134204 A1Published application
Complexes made using low solubility drugs
OwnerPatrick Wong, Dong Yaninventors
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Abstract
Disclosed herein are substances that include a complex that includes a drug moiety ionically bound to a counter-ion; wherein a solubility of the complex is greater than a solubility of the drug moiety. Also disclosed are compositions and dosage forms made from such substances and complexes; methods of making compositions, substances, and complexes; and methods of administering the same to patients.
Claims35
A substance comprising:
- a complex comprising a drug moiety ionically bound to a counter-ion;
- wherein a solubility of the complex is greater than a solubility of the drug moiety.
A method of preparing a substance comprising:
- providing a drug moiety;
- mixing the drug moiety into a solvent that has been titrated to a pH as follows:
- (a) for acidic structural elements or acidic residual structural elements, the the environmental pH is less than or equal to about the pKa of the drug moiety minus two pH units,
- (b) for basic structural elements or basic residual structural elements, the environmental pH is greater than or equal to about the pKa of the drug plus two pH units;
- adding a counter-ion to the mixture of the drug moiety and the solvent;
- forming a complex that comprises the drug moiety and the counter-ion;
- and
- recovering the complex.
5 more elements
A method comprising:
- providing a complex comprising a drug moiety ionically bound to a counter-ion;
- wherein a solubility of the complex is greater than a solubility of the drug moiety;
- and
- administering the complex to a patient.
1 more element
Dependencies are inferred from the claim text.