Mannose-based fast dissolving tablets
OwnerYourong Fu, Seong Jeong +6inventors
InventorsYourong Fu, Seong Jeong, Jeanny Kim, Jacqueline Callihan, Kinam Park, Chaul Pai, Sang Yeob Park, Gun Seomoon
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Abstract
Fast-dissolving pharmaceutical tablets comprising mannose are described. The mannose component imparts both structure-forming and fast-dissolution properties to the tablets. Granulation of tablet components and humidification forms strong liquid bridges at the surface interfaces of mannose particles, which leads to strengthened tablets. The mannose particles, however, remain porous following compression so that contact with moisture, e.g., saliva in the mouth, leads rapidly to tablet disintegration and dissolution.
Claims30
A fast-dissolving pharmaceutical tablet comprising a dissolution-effective amount of mannose, which tablet has a hardness of at least about 20 newtons and which disintegrates within about 30 seconds in the presence of an amount of water sufficient to soak the tablet.
A method of making a pharmaceutical tablet having fast-dissolving properties, comprising:
- a. providing mannose, and optionally a drug compound in admixture therewith;
- b. compressing the mannose-containing composition;
- c. subjecting the compressed composition to relative humidity conditions of at least about 50% RH;
- and
- d. drying the humidified, compressed composition to form the tablet.
Dependencies are inferred from the claim text.