Formulations of bisphosphonate drugs with improved bioavailability
AssigneeBanner Pharmacaps, Inc.
InventorsTae Kim, Aqeel Fatmi
Life of this patent
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Abstract
This invention relates to formulations of bisphosphonates such as alendronate. The formulations taught herein enhance bioavailability of bisphosphonates and reduce esophageal and gastric ulcerations associated with them. Also taught herein are methods of preparing the formulations and their clinical use in the treatment of osteoporosis and other bone diseases.
Claims28
A pharmaceutical formulation comprising a therapeutic amount of a bisphosphonate or pharmaceutically acceptable salt thereof temporarily complexed with a pharmacologically acceptable complexing agent, and optionally comprising one or more pharmaceutically acceptable excipients and optionally comprising one or more pharmaceutically acceptable carriers.
A pharmaceutical formulation comprising a therapeutic amount of a bisphosphonate or pharmaceutically salt thereof, one or more oils, one or more waxes, or a combination thereof, a surfactant, and optionally water.
A pharmaceutical formulation comprising a therapeutic amount of a bisphosphonate or pharmaceutically salt thereof, and optionally one or more pharmaceutically acceptable excipients and optionally one or more pharmaceutically acceptable carriers in an enteric capsule.
A method of improving the bioavailability of a bisphosphonate comprising forming a temporary complex of the bisphosphonate or pharmaceutically salt thereof with a pharmacologically acceptable complexing agent and administering the resulting complex, optionally in a formulation with one or more pharmaceutically acceptable excipients, to a patient in need thereof.
An enteric soft gelatin capsule comprising an enteric gelatin shell with a filling comprised of a therapeutic amount of a bisphosphonate or pharmaceutically salt thereof temporarily complexed with a pharmacologically acceptable complexing agent, as a solution, suspension, gel, or paste, and optionally one or more pharmaceutically acceptable excipients.
A method of treating a patient suffering from resorption of bone comprising administering to the patient a therapeutic amount of a bisphosphonate or pharmaceutically salt thereof temporarily complexed with a pharmacologically acceptable complexing agent.
Dependencies are inferred from the claim text.