Transdermal pharmaceutical preparation with a progesterone A-specific ligand (PRASL) as active ingredient

A method of making a transdermal patch,

• wherein said transdermal patch comprises a backing layer, at least one effective-ingredient-containing adhesive layer adhering to the backing layer and a removable protective film, wherein said at least one effective-ingredient-containing adhesive layer comprises an effective ingredient and an adhesive matrix based on a silicone polymer, a polyisobutylene polymer, a polyacrylate polymer or a styrene block copolymer with butadiene or isoprene;
• wherein said effective ingredient is contained in a concentration of from 0.1 to 10%, based on a total weight of the adhesive matrix;
• and
• wherein said effective ingredient is a compound of formula I:
• wherein R1 and R2 each represent, independently of each other, H or F;
• R3 represents CH3 or CF3 and
• Ar is a group of formula II or III:
• or a pharmaceutically suitable derivative thereof (progesterone A-specific ligand, PRASL);
• and
• wherein said method comprises the steps of:
• a) taking up the effective ingredient in a combination of solvents having a comparatively low solubility for the effective ingredient and a solvent having a comparatively high solubility for the effective ingredient to form an effective-ingredient-containing mixture;
• b) mixing the effective-ingredient-containing mixture with the adhesive matrix to form a resulting batch;
• and
• c) removing the solvent having the comparatively high solubility for the effective ingredient from the resulting batch.