Amphiphilic block copolymers and their use
AssigneeAMO Groningen B.V.
InventorsYan Liu, Jons Hilborn, Hendrik Haitjema, Sverker Norrby, Thom Terwee
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Abstract
The present invention relates to amphiphilic block copolymers comprising at least one block of hydrophilic units and at least one block of hydrophobic units, wherein at least one hydrophobic block contains siloxane units. The present invention may be particularly useful as a tissue adhesive or as a coating for an intraocular lens (IOL). As an IOL coating, copolymers according to the invention may be used, for example, to promote tissue adhesion for the prevention of posterior capsule opacification.
Claims35
A coating composition for adhering an implant to a biological tissue comprising an amphiphilic block copolymer having at least one block of hydrophilic units and at least one block of hydrophobic units characterized in that said at least one hydrophobic block contains siloxane units.
An amphiphilic block copolymer comprising at least one block of hydrophilic units and at least one block of hydrophobic units characterized in that said at least one hydrophobic block contains siloxane units and said at least one hydrophilic block comprises terminal or lateral functional groups.
An ophthalmic lens at least partially coated with a coating composition comprising an amphiphilic block copolymer having at least one block of hydrophilic units and at least one block of hydrophobic units characterized in that said at least one hydrophobic block contains siloxane units.
A method for providing a connection between a tissue surface and an implant or drug delivery device, comprising applying a composition between the tissue surface and the implant or drug delivery device, wherein the composition comprises an amphiphilic block copolymer having at least one block of hydrophilic units and at least one block of hydrophobic units characterized in that said at least one hydrophobic block contains siloxane units.
A method for reducing secondary cataract characterized in that a composition is injected into the capsular bag of an eye, wherein the composition comprises an amphiphilic block copolymer having at least one block of hydrophilic units and at least one block of hydrophobic units characterized in that said at least one hydrophobic block contains siloxane units.
A joint structure characterized in that said structure comprises amphiphilic block copolymers in which at least one hydrophilic block interacts with the tissue surface and in which at least one hydrophobic block comprises hydrophobic polymers capable of interacting with an implant whereby a laminate comprising the tissue surface, amphiphilic copolymers and the implant is obtained.
Dependencies are inferred from the claim text.