Polysiloxanes, method of synthesis and ophthalmic compositions
OwnerYan Liu, Jons Hilborn +1inventors
InventorsYan Liu, Jons Hilborn, Hendrik Haitjema
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Abstract
A linear polysiloxane copolymer has at least one terminal hydroxyalkyl group. The copolymer is preparable by a process comprising a combination of a base-catalysed polymerisation with an acid-catalysed redistribution, and is suitable for preparing ophthalmic compositions for forming an intraocular lens in situ.
Claims19
A linear polysiloxane copolymer having at least one terminal hydroxyalkyl group.
An injectable ophthalmic composition suitable for forming an intraocular lens in the capsular bag of an eye, comprising the linear polysiloxane copolymer having at least one terminal hydroxyalkyl group in which the at least one hydroxyalkyl group has been converted to an acryl group.
An injectable ophthalmic composition suitable for forming an intraocular lens in the capsular bag of an eye, comprising a mixture of di-functional copolymer and mono-functional copolymer, wherein each functional copolymer comprises a linear polysiloxane copolymer having at least one terminal hydroxyalkyl group, and non-functional copolymers having essentially the same structure as said functional copolymers.
A process for preparing a linear siloxane polymer, comprising
- (a) polymerizing siloxane monomers in a base catalysed polymerization reaction;
- (b) introducing terminal alkyl groups to the polymer of step (a) by an acid catalyst redistribution process;
- and
- (c) hydrolyzing the polymer obtained in step (b) to yield hydroxyalkyl-terminated polysiloxane.
A method for producing an intraocular lens, comprising the steps of:
- a. injecting a. composition into an empty capsular bag of the eye, the composition comprising a linear polysiloxane copolymer having at least one terminal hydroxyalkyl group in which the at least one hydroxyalkyl group has been converted to an acryl group;
- and
- b. initiating a polymerisation reaction whereby an intraocular lens is obtained.
Dependencies are inferred from the claim text.