Agents which regulate, inhibit, or modulate the activity and/or expression of lysyl oxidase (LOX) and LOX-like proteases as a unique means to both lower intraocular pressure and treat glaucomatous retinopathies/optic neuropathies
AssigneeAlcon Inc.
InventorsAllan Shepard, Abbot Clark, Mark Hellberg
Life of this patent
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Abstract
The present invention provides a method for lowering intraocular pressure and providing neuroprotection to a patient in need thereof by administering a therapeutically effective amount of at least one non-nucleotide or non-protein agent that inhibits expression and/or signaling of lysyl oxidase (LOX) or a lysyl oxidase-like protease (LOXL).
Claims15
A method for lowering intraocular pressure and providing neuroprotection to a patient in need thereof, said method comprising administering a therapeutically effective amount of a composition comprising at least one non-nucleotide or non-protein agent that inhibits expression, signaling or biological functions of lysyl oxidase (LOX), and a pharmaceutically acceptable carrier.
The method of claim 5, wherein said glaucoma is normal-tension glaucoma.
A method for lowering intraocular pressure in a patient in need thereof, said method comprising administering a therapeutically effective amount of a composition comprising at least one non-nucleotide or non-protein agent that inhibits expression, signaling, or biological functions of lysyl oxidase (LOX), and a pharmaceutically acceptable carrier.
The method of claim 7, wherein said administering is by topical application, intracamerally or via an implant.
The method of claim 11, wherein said glaucoma is normal-tension glaucoma.
A method for lowering intraocular pressure in a patient in need thereof, said method comprising administering a therapeutically effective amount of a composition comprising at least one non-nucleotide or non-protein agent that inhibits the expression, signaling, or biological functions of a lysyl oxidase-like (LOXL) protease selected from the group consisting of LOXL1, LOXL2, LOXL3, and LOXL4.
A composition for lowering intraocular pressure and providing neuroprotection in a patient in need thereof, said composition comprising at least one agent that inhibits the expression, signaling, or biological functions of lysyl oxidase (LOX) and a pharmaceutically acceptable carrier.
A composition for lowering intraocular pressure and providing neuroprotection in a patient in need thereof, said composition comprising at least one agent that inhibits the expression, signaling, or biological functions of a lysyl oxidase-like protease (LOXL) selected from the group consisting of LOXL1, LOXL2, LOXL3, and LOXL4, and a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.