Th2-inducing adjuvant treatment for osteolysis
OwnerThomas DiMauro, Mohamed Attawia +2inventors
InventorsThomas DiMauro, Mohamed Attawia, Chantal Holy, Hugo Pedrozo
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Abstract
Active immunization and a formulation for treating or preventing osteolysis caused by Wear Particles, comprising: a) a Th2 -inducing adjuvant, and b) Wear Particles.
Claims49
A method of preventing or treating osteolysis comprising the steps of:
- a) administering to a patient a formulation comprising:
- i) a Th2-inducing adjuvant, and
- ii) Wear Particles.
A formulation for treating or preventing osteolysis caused by Wear Particles, comprising:
- i) a Th2-inducing adjuvant, and
- ii) Wear Particles.
A kit comprising:
- a) a formulation adapted to elicit a Th2 immune response, and
- b) an orthopedic implant having an articulation interface.
An orthopedic implant having surface having a coating thereon, wherein the coating is adapted to elicit a Th2 immune response.
A formulation for treating or preventing osteolysis caused by Wear Particles, comprising:
- a) a Th2-inducing adjuvant, and
- b) particles selected from the group consisting of a polymer, titanium, titanium alloy, cobalt chrome, and PMMA, and mixtures thereof.
A formulation for treating or preventing osteolysis caused by Wear Particles, comprising:
- a) a Th2-inducing adjuvant, and
- b) particles having a D50 particle size of between 0.1 um and 10 um.
A method of preventing or treating sciatica from a nucleus pulposus of a patient, comprising the steps of:
- a) administering to the patient a formulation comprising:
- i) a Th2-inducing adjuvant, and
- ii) nucleus pulposus.
Dependencies are inferred from the claim text.