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AssigneeChemical Biology Institute
InventorsTokifumi Majima, Norimasa Iwasaki, Tadanao Funakoshi, Akio Minami, Shin-ichiro Nishimura, Seiichi Tokura, Kazuo Harada, Sachiko Nonaka, Nobuhiki Maekawa
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It is intended to provide a three-dimensional scaffolds appropriate for culturing animal cells such as chondrocytes and fibroblasts. These three-dimensional scaffolds which comprise a chitosan/acidic biopolymers hybrid fibers composed of chitosan or its salts in the inside of the fiber and complexes of chitosan with biodegradable acidic biopolymers coating the fiber surface, are made of fibers capable of retaining their shapes after allowing to stand Dulbecco's modified Eagle's medium (DMEM) containing 10% of FBS (fetal bovine serum) at room temperature for 2 weeks.
A chitosan/acidic biopolymers hybrid fibers in which the inner part of the fibers comprises chitosan or salts thereof and the surface of the fibers are covered by a complex of chitosan and a biodegradable acidic biopolymers and which retains the form thereof when the fibers are soaked in DMEM medium (Dulbecco's Modified Eagle's Medium) at room temperature for 2 weeks.
Dependencies are inferred from the claim text.