Propofol-containing fat emulsions
AssigneeOtsuka Pharmaceutical Factory, Inc.
InventorsKenji Matsuda, Koichi Takeda, Toshimitsu Terao, Tadaaki Inoue
Life of this patent
Estimating the term…
Abstract
The present invention provides a propofol-containing fat emulsion comprising propofol, an oily component, and an emulsifier, and further comprising a predetermined amount of a stabilizer, such as phosphatidylglycerol in which a specific fatty acid is a constituent fatty acid component. The present invention also provides a pain-relieving propofol-containing fat emulsion, which is obtained by mixing a local anaesthetic in advance with the above-described propofol-containing fat emulsion of the invention.
Claims34
A fat emulsion with which a local anaesthetic is mixed before use, and which comprises propofol, an oily component, and an emulsifier, the fat emulsion further comprising a stabilizer selected from the following (a), (b), (c), or (d):
- (a) at least one phospholipid selected from the group consisting of phosphatidylglycerol, phosphatidic acid, phosphatidylinositol, and phosphatidylserine wherein a fatty acid esterified to a glycerol moiety is a C8-22 linear or branched, saturated or unsaturated fatty acid;
- (b) at least one phospholipid derivative selected from phosphatidylethanolamines modified with polyalkyleneglycol, wherein a fatty acid esterified to a glycerol moiety is a C10-22 linear or branched, saturated or unsaturated fatty acid;
- (c) at least one fatty acid selected from the group consisting of C10-22 linear or branched, saturated or unsaturated fatty acids;
- or
- (d) a mixture of at least two members selected from the above groups (a), (b), and (C), wherein
- the stabilizer (a), (b), or (c) is present at a concentration of 0.01 to 1 w/v %, 0.01 to 1 w/v %, 0.05 to 5 w/v %, respectively, per the total amount of fat emulsion and local anaesthetic to be mixed therewith before use.
(canceled)
(canceled)
(canceled)
A pain-relieving fat emulsion comprising propofol, an oily component, an emulsifier, a stabilizer, and a local anaesthetic, wherein the stabilizer is selected from the following (a), (b), (c), or (d):
- (a) at least one phospholipid selected from the group consisting of phosphatidylglycerol, phosphatidic acid, phosphatidylinositol, and phosphatidylserine wherein a fatty acid esterified to a glycerol moiety is a C18-22 linear or branched, saturated or unsaturated fatty acid;
- (b) at least one phospholipid derivative selected from phosphatidylethanolamines modified with polyalkyleneglycol, wherein a fatty acid esterified to a glycerol moiety is a C10-22 linear or branched, saturated or unsaturated fatty acid;
- (c) at least one fatty acid selected from the group consisting of C10-22 linear or branched, saturated or unsaturated fatty acids;
- or
- (d) a mixture of at least two members selected from the above groups (a), (b), and (C), wherein
- the stabilizer (a), (b), or (c) is present at a concentration of 0.01 to 1 w/v %, 0.01 to 1 w/v %, and 0.05 to 5 w/v %, respectively, in the fat emulsion.
(canceled)
(canceled)
(canceled)
A method for manufacturing a pain-relieving fat emulsion, the method comprising:
- mixing a local anaesthetic with a fat emulsion comprising propofol, an oily component, an emulsifier, and a stabilizer, wherein the stabilizer is selected from the following (a), (b), (c), or (d):
- (a) at least one phospholipid selected from the group consisting of phosphatidylglycerol, phosphatidic acid, phosphatidylinositol, and phosphatidylserine wherein a fatty acid esterified to a glycerol moiety is a C18-22 linear or branched, saturated or unsaturated fatty acid;
- (b) at least one phospholipid derivative selected from phosphatidylethanolamines modified with polyalkyleneglycol, wherein a fatty acid esterified to a glycerol moiety is a C10-22 linear or branched, saturated or unsaturated fatty acid;
- (c) at least one fatty acid selected from the group consisting of C10-22 linear or branched, saturated or unsaturated fatty acids;
- or
- (d) a mixture of at least two members selected from the above groups (a), (b), and (c), to thereby obtain a fat emulsion, wherein
- the stabilizer (a), (b), or (c) is present at a concentration of 0.01 to 1 w/v %, 0.01 to 1 w/v %, and 0.05 to 5 w/v %, respectively, in the fat emulsion.
(canceled)
Dependencies are inferred from the claim text.