Poly-gamma-glutamic conjugates for eliciting immune responses directed against bacilli
AssigneeThe United States of America, as represented by the Secretary, Department of Health and Human Services
InventorsRachel Schneerson, Stephen Leppla, John Robbins, Joseph Shiloach, Joanna Kubler-Kielb, Darrell Liu, Fathy Majadly
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Abstract
Immunogenic compositions and methods for eliciting an immune response against B. anthracis and other bacilli are provided that include immunogenic conjugates of a poly-γ-glutamic acid (γPGA) polypeptide of B. anthracis, or of another Bacillus that expresses a γPGA polypeptide. The γPGA conjugates elicit an effective immune response against B. anthracis, or against another Bacillus, in mammalian hosts to which the conjugates are administered.
Claims36
An immunogenic conjugate comprising a a synthetic homopolymer polypeptide of poly-γ-glutamic acid (γPGA) polypeptide covalently linked to a carrier, wherein the conjugate elicits an immune response in a subject.
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23-33. (canceled)
An immunogenic conjugate comprising a Bacillus capsular poly-γ-glutamic acid (γPGA) polypeptide covalently linked to a carrier, wherein the carrier is selected from the group consisting of:
- (a) recombinant B. anthracis protective antigen, (b) recombinant P. aeruginosa exotoxin A, (c) tetanus toxoid, (d) diphtheria toxoid, (e) pertussis toxoid, (f) C. perfringens toxoid, (g) hepatitis B surface antigen, (h) hepatitis B core antigen, (i) keyhole limpet hemocyanin, (j) horseshoe crab hemocyanin, (k) edestin, (l) mammalian serum albumins, analogs or mimetics of (a)-(l), and combinations thereof, and wherein the conjugate elicits an immune response in a subject.
Dependencies are inferred from the claim text.