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US 2006/0134142 A1Published application
Modified streptococcal polysaccharides and uses thereof
AssigneeThe Brigham and Women's Hospital, Inc.
InventorsDennis Kasper, Hilde-Kari Guttormsen
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Abstract
Modified streptococcal polysaccharides and methods of using the modified polysaccharides are provided herein.
Claims71
An antigenic composition comprising:
- (a) a modified group B streptococcus (GBS) type V polysaccharide;
- and
- (b) a moiety that is covalently associated with the polysaccharide.
A method for eliciting an immune response in a mammal, the method comprising administering to the mammal a composition comprising:
- (a) a modified group B streptococcus (GBS) type V polysaccharide;
- and
- (b) a moiety that is covalently associated with the polysaccharide;
- thereby eliciting an immune response in the mammal.
1 more element
A method of providing antibodies to a neonate, the method comprising:
- administering to a pregnant female an antigenic composition comprising:
- (a) a modified group B streptococcus (GBS) type V polysaccharide;
- and
- (b) a moiety that is physically associated with the polysaccharide.
1 more element
A method for preparing an immunogenic composition, the method comprising:
- providing a purified GBS V polysaccharide;
- treating the polysaccharide under conditions that modify the structure of the polysaccharide.
Dependencies are inferred from the claim text.