Immunosuppression
AssigneeML Laboratories PLC
InventorsRobert Lechler, Nichola Rogers, Anthony Dorling
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Abstract
The invention herein described relates to a method to improve the tolerance of a mammal, preferably a human, to a xenograft through immunisation of the recipient mammal with an immunogen comprising both a B cell epitope derived from porcine polypetides and T cell epitope. The invention also encompasses immunogenic compositions comprising said immunogens and methods to monitor the status of the xenograft.
Claims26
A method of improving tolerance to a xenograft comprising:
- immunising a mammal with an immunogen comprising at least one T-cell epitope and at least one porcine polypeptide B-cell epitope, wherein said B-cell epitope is capable of mediating rejection of said xenograft.
A composition comprising an immunogen characterised in that said immunogen comprises at least one B-cell epitope and at least one T-cell epitope wherein said B-cell epitope comprises a porcine epitope involved in mediating xenograft rejection.
Dependencies are inferred from the claim text.