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US 2006/0134121 A1Published application
DII4 antagonists, assays, and therapeutic methods thereof
OwnerGavin Thurston, Nicholas Gale +1inventors
InventorsGavin Thurston, Nicholas Gale, Irene Noguera
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Abstract
Methods for screening for agents capable of inhibiting Dll4 are provided, as well as therapeutic methods for treating Dll4-mediated conditions. More specifically, methods are provided for identifying agents capable of inhibiting blood vessel growth and formation, such as antibodies to human DLL4.
Claims11
A method for identifying an agent capable of binding a Dll4 protein, or protein fragment, comprising:
- (a) contacting a test agent with a Dll4 protein, or protein fragment;
- and
- (b) determining the ability of the test agent to bind Dll4 protein or protein fragment.
A method for identifying an agent capable of inhibiting Dll4 activity, comprising:
- (a) administering a test agent to an animal expressing a Dll4 protein, or protein fragment;
- and
- (b) determining the ability of the test agent to inhibit Dll4 activity.
An antibody capable of blocking human Dll4 binding activity.
Dependencies are inferred from the claim text.