Loading patent…
AssigneeTakeda Pharmaceutical Company Limited
InventorsTakafumi Ishii, Koji Yamamoto, Eiji Sunahara, Shuji Sato
Estimating the term…
A compound inhibiting the activity of a protein comprising the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 1, SEQ ID NO: 4, SEQ ID NO: 7, SEQ ID NO: 10, SEQ ID NO: 15, SEQ ID NO: 17, SEQ ID NO: 20, SEQ ID NO: 22, SEQ ID NO: 25 or SEQ ID NO: 27, or a salt thereof; a compound inhibiting the expression of a gene of the protein; an antisense polynucleotide containing the entire or part of a base sequence complementary or substantially complementary to a base sequence of a polynucleotide encoding the protein or its partial peptide; an antibody to the protein or its partial peptide, etc. are useful as prophylactic/therapeutic agents for cancer, etc., apoptosis promoters for cancer cells, and the like.
A protein comprising the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO:
A protein consisting of the amino acid sequence represented by SEQ ID NO:
A polynucleotide consisting of a base sequence represented by SEQ ID NO:
-16. (canceled)
-20. (canceled)
-23. (canceled)
-27. (canceled)
An antisense polynucleotide comprising the entire or part of a base sequence complementary or substantially complementary to a base sequence of a polynucleotide encoding a protein comprising the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO:
(canceled)
An antibody to a protein comprising the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO:
-36. (canceled)
A prophylactic/therapeutic agent for a cancer, comprising a compound or its salt inhibiting the activity of a protein comprising the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO:
A prophylactic/therapeutic agent for a cancer, comprising a compound or its salt inhibiting the expression of a gene for a protein comprising the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO:
A method of screening a prophylactic/therapeutic agent for a cancer, which comprises using a protein comprising the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO:
A kit for screening a prophylactic/therapeutic agent for a cancer, comprising a protein comprising the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO:
(canceled)
A method of screening a prophylactic/therapeutic agent for a cancer, which comprises using a polynucleotide encoding a protein comprising the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO:
A kit for screening a prophylactic/therapeutic agent for a cancer, comprising a polynucleotide encoding a protein comprising the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO:
-45. (canceled)
A method of screening an apoptosis promoter, which comprises using a protein comprising the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO:
A method of screening an apoptosis promoter, which comprises using a polynucleotide encoding a protein comprising the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO:
-50. (canceled)
Dependencies are inferred from the claim text.