G protein coupled receptors and uses thereof

A substantially pure polypeptide comprising a polypeptide sequence listed in Table 2.

A substantially pure polypeptide having at least 90% sequence identity to a polypeptide listed in Table 2.

A substantially pure polynucleotide encoding a polypeptide listed in Table 2.

A method for determining whether a patient has an increased risk for developing a neurological disease or disorder, said method comprising determining the presence of a mutation in the patient's gene encoding a GPCR polypeptide substantially identical to a polypeptide listed in any one of Tables 3-14 and 33, wherein the presence of said mutation indicates that said patient has an increased risk for developing a neurological disease or disorder.

A method for determining whether a patient has an increased risk for developing a neurological disease or disorder, said method comprising measuring in said patient or in a cell from said patient the level of biological activity of a GPCR polypeptide substantially identical to a polypeptide listed in any one of Tables 3-14 and 33,wherein an altered level in said biological activity, relative to normal, indicates that said patient has an increased risk for developing a neurological disease or disorder.

A method for determining whether a patient has an increased risk for developing a neurological disease or disorder, said method comprising measuring in said patient or in a cell from said patient the expression of a GPCR polypeptide substantially identical to a polypeptide listed in any one of Tables 3-14 and 33, wherein altered levels in said expression, relative to normal levels, indicates that said patient has an increased risk for developing a neurological disease or disorder.

A method for determining whether a patient has an increased risk for developing a neurological disease or disorder, comprising determining the presence of a polymorphism in the patient's gene encoding a GPCR polypeptide substantially identical to a polypeptide listed in any one of Tables 3-14 and 33, wherein the presence of said polymorphism associated with a neurological disease or disorder indicates the person has an altered risk for developing a neurological disease or disorder.

A method of treating or preventing a neurological disease or disorder in a patient, said method comprising administering to said patient a nucleic acid molecule encoding a GPCR polypeptide substantially identical to a polypeptide listed in any one of Tables 3-14 and 33.

A method of treating or preventing a neurological disease or disorder in a patient, said method comprising administering to said patient an expression vector comprising a nucleic acid molecule operably linked to a promoter, said nucleic acid molecule encoding a GPCR polypeptide substantially identical to a polypeptide listed in any one of Tables 3-14 and 33.

A method of treating or preventing a neurological disease or disorder in a patient, said method comprising administering to said patient a compound that modulates the biological activity of a GPCR polypeptide substantially identical to a polypeptide listed in any one of Tables 3-14 and 33.

A method for identifying a compound that may be useful for the treatment or prevention of a neurological disease or disorder, said method comprising the steps of contacting a GPCR polypeptide substantially identical to a polypeptide listed in any one of Tables 3-14 and 33, and a candidate compound;

• and determining whether said candidate compound interacts with said GPCR polypeptide, wherein interaction between said candidate compound and said GPCR polypeptide identifies said candidate compound as a compound that may be useful for the treatment or prevention of a neurological disease or disorder.

A method for identifying a compound that may be useful for the treatment or prevention of a neurological disease or disorder, said method comprising the steps of contacting a GPCR polypeptide substantially identical to a polypeptide listed in any one of Tables 3-14 and 33, and disposed in a lipid membrane with a candidate compound;

• and determining whether said candidate compound interacts with said GPCR polypeptide wherein interaction between said candidate compound and said GPCR polypeptide identifies said candidate compound as a compound that may be useful for the treatment or prevention of a neurological disease or disorder.

A mouse comprising a mutation in a gene encoding a polypeptide that is substantially identical to a polypeptide listed in Table 1.

A method of making a mouse exhibiting altered behavior, said method comprising the step of introducing into said mouse a mutation in a gene encoding a polypeptide comprising a polypeptide listed in any one of Tables 3-14 and 33.

A cell isolated from a non-human mammal comprising a transgene comprising a nucleic acid molecule encoding a GPCR related polypeptide.

A cell isolated from a non-human mammal comprising a mutation in a gene encoding a polypeptide that is substantially identical to a polypeptide listed in Table 1.

A transgenic mouse expressing a transgene encoding a human GPCR polypeptide listed in Table 1.

A transgenic mouse expressing a transgene encoding a mouse GPCR polypeptide listed in Table 1.

A method for identifying a compound that may be useful for the treatment of a neurological disease or disorder, said method comprising the steps of administering a candidate compound to a transgenic mouse expressing a transgene encoding a human GPCR polypeptide listed in any one of Tables 3-14 and 33;

• and determining whether said candidate compound alters the biological activity of said GPCR polypeptide, wherein a alteration in the biological activity of said GPCR polypeptide identifies said candidate compound as a compound that may be useful for the treatment of a neurological disease or disorder.

A method for identifying a compound that may be useful for the treatment of a neurological disease or disorder, said method comprising the steps of administering a candidate compound to a transgenic mouse expressing in one its neurological tissues a transgene encoding a human GPCR polypeptide listed in any one of Tables 3-14 and 33, said mouse having a neurological disease or disorder;

• and determining whether said candidate compound treats said neurological disease or disorder.

A method for identifying a compound that may be useful for the treatment of a neurological disease or disorder, said method comprising the steps of contacting a candidate compound with a cell from a transgenic mouse expressing a transgene encoding a human GPCR polypeptide listed in any one of Tables 3-14 and 33;

• and determining whether said candidate compound alters the biological activity of said GPCR polypeptide, wherein a alteration in the biological activity of said GPCR polypeptide identifies said candidate compound as a compound that may be useful for the treatment of a neurological disease or disorder.

A method for identifying a compound that may be useful for the treatment of a neurological disease or disorder, said method comprising the steps of administering a candidate compound to a transgenic mouse comprising a mutation in a GPCR polypeptide listed in Tables 3-14 and 33;

• and determining whether said candidate compound alters the biological activity of said GPCR polypeptide, wherein an alteration in the biological activity of said GPCR polypeptide identifies said candidate compound as a compound that may be useful for the treatment of a neurological disease or disorder.