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AssigneesBiotechnology Foundation, Inc., University of Oxfprd
InventorsHilary Koprowski, Kisung Ko, Pauline Rudd, Raymond Dwek, Yoram Tekoah
Estimating the term…
Human rabies monoclonal antibodies (rabies MAbP) comprising rabies human MAb S057 heavy chain and light chain subunits are expressed and assembled in plants under the control of two strong constitutive promoters. Additionally, regulatory control elements such as alfalfa mosaic virus untranslated leader sequence and Lys-Asp-Glu-Leu (KDEL) endoplasmic reticulum retention signal were linked at the N- and C-terminus of the heavy chain of human rabies MAbP, respectively to regulate expression of the rabies MAbP. Rabies MAbP was as effective at neutralizing the activity of the rabies virus as the mammalian-derived antibody (MAbM) or human rabies immunoglobulin (HRIG).
A plant-derived human monoclonal antibody comprising a rabies MAbP, wherein the rabies MAbP contains predominantly oligomannose type N-glycans and has substantially reduced or no α(1,3)-linked fucose residues.
An expression vector comprising, one or more gene constructs comprising polynucleotides encoding one or more rabies human MAb S057 subunits under the control of one or more promoters, operatively linked to regulatory control elements and Agrobacterium T-DNA terminal repeats.
A pharmaceutical composition for treating, ameliorating or preventing a rabies virus related disease or disorder comprising a pharmaceutically effective amount of a plant-derived human monoclonal antibody comprising a rabies MAbP, and a pharmaceutically acceptable carrier or diluent.
A vaccine composition to induce passive immunity against rabies infection in humans comprising a rabies MAbP S057, and an adjuvant.
A diagnostic test kit for detection of rabies infection comprising a rabies MAbP and a detection agent comprising a detectable label.
A plant-derived human monoclonal antibody comprising a a rabies MAbP, wherein the a rabies MAbP comprises an endoplasmic reticulum retention signal, and contains about 70% oligomannose type N-glycans.
Dependencies are inferred from the claim text.