Treatment of cancer by simultaneous inhibiton of BRAF and restoration or mimicry of p16INK4A activity
AssigneeMount Sinai School of Medicine of New York University
InventorJianli Dong
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Abstract
Provided is a method for inhibiting growth of a tumor cell which comprises oncogenically activated BRAF and defective p16INK4A by inhibiting activated BRAF and restoring functional p16INK4A. Also provided is a method for sensitizing the foregoing tumor cell to cytotoxic or cytostatic effect of a chemotherapeutic agent or radiation by further contacting the cell with such an agent. Also provided is a method for treating cancer, especially melanoma, by simultaneously inhibiting expression or activity of activated BRAF and restoring or mimicking the activity of wild-type p16INK4A.
Claims53
A method for inhibiting the growth of a tumor cell that comprises an oncogenically activated BRAF protein, and is defective in the expression of a functional p16INK4A protein, comprising:
- (a) inhibiting expression or activity of the oncogenically activated BRAF in the tumor cell;
- and
- (b) restoring functional p16INK4A activity in the tumor cell.
A method for sensitizing a tumor cell to the cytotoxic or cytostatic effect of a chemotherapeutic agent or radiation,-wherein the tumor cell comprises an oncogenically activated BRAF protein, and defective expression of a functional p16INK4A protein, comprising:
- (a) inhibiting expression or activity of BRAF in the tumor cell;
- (b) restoring functional activity of p16INK4A in the tumor cell;
- and
- (c) contacting the cell with an effective amount of a chemotherapeutic agent.
A method for treating cancer in an individual having a tumor comprising an oncogenically activated BRAF protein, and having defect in the expression or activity of a functional p16INK4A protein, comprising:
- (a) inhibiting expression or activity of oncogenically activated BRAF in the tumor cell;
- and
- (b) restoring functional p16INK4A activity in the tumor cell.
Dependencies are inferred from the claim text.