Composition comprising the polyprotein NS3/NS4 and the polypeptide NS5B of HCV, expression vectors including the corresponding nucleic sequences and their therapeutic use
AssigneesTransgene S.A., Institut National de la Sante et de la Recherche Medicale
InventorAnne Fournillier
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Abstract
The invention relates to a peptidic compound containing a polyprotein NS3/NS4 of a hepatitis C virus and a polypeptide NS5b of hepatitis C virus. Said invention also relates to expression vectors such as adenovirus and poxyvirus in which nucleic sequences coding for the polyprotein NS3/NS4 and the polypeptide NS5b. The inventive compound can be used for a therapeutic application.
Claims18
1-17. (canceled)
Peptide composition characterized in that it comprises a polyprotein NS3/NS4 of the hepatitis C virus, as well as a polypeptide NS5b of the hepatitis C virus.
Expression vector characterized in that it comprises a nucleotide sequence coding for the polyprotein NS3/NS4 and a nucleotide sequence coding for the polypeptide NS5b, as well as the means necessary to their expression.
Pharmaceutical kit, in particular vaccinal, characterized in that it comprises at least one expression vector comprising a nucleotide sequence coding for the polyprotein NS3/NS4 and at least one expression vector comprising a nucleotide sequence coding for the Polypeptide NS5b.
Pharmaceutical kit, in particular vaccinal, characterized in that it comprises:
- at least one expression vector characterized in that it comprises a nucleotide sequence coding for the polyprotein NS3/NS4 and a nucleotide sequence coding for the polypeptide NS5b, as well as the means necessary to their expression, wherein said vector is an adenovirus;
- and
- at least one expression vector characterized in that it comprises a nucleotide sequence coding for the polyprotein NS3/NS4 and a nucleotide sequence coding for the polypeptide NS5b, as well as the means necessary to their expression, wherein said vector is a poxvirus.
Dependencies are inferred from the claim text.