Polymer composition for pH dependent dissolution behavior and process for preparation thereof
AssigneeCouncil of Scientific and Industrial Research
InventorsMohan Kulkarni, Anupa Menjoge
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Abstract
The present invention relates a novel pH sensitive polymer which exhibits pH dependant swelling/dissolution behavior. The composition is useful for taste masking of bitter drugs and also for the gastric delivery of the drugs. The said polymer comprises a hydrophobic monomer polymerized along with a basic monomer or a hydrophobic monomer polymerized along with a basic monomer and a hydrophilic monomer.
Claims26
A polymer which exhibits pH dependent swelling/dissolution behavior, having the formula
- P[A(x)B(y)C(z)]
- wherein P is a pH sensitive polymer comprising (A) a hydrophobic monomer, (B) a basic monomer and (C) a hydrophilic monomer and (x)=30-95%, (y)=5-70%, (z)=0-60%, all percentages expressed in terms of w/w, wherein the hydrophilic monomer (C) comprises an acrylic or methacrylic acid ester selected from the group consisting of hydroxy ethyl methacrylate, hydroxy propyl methacrylate, hydroxyethyl ethyl methacrylate, hydroxy ethyl acrylate, hydroxy propyl acrylate, hydroxyethyl ethyl acrylate wherein the hydrophilic monomer (C) is selected from hydroxy ethyl methacrylate and hydroxyethyl ethyl methacrylate.
A process for the preparation of a polymer which exhibits pH dependent swelling/dissolution behavior, having the formula P[A(x) B(y)C(z)] wherein P is a pH sensitive polymer comprising (A) a hydrophobic monomer, (B) a basic monomer and (C) a hydrophilic monomer and (x)=30-95%. (y)=5-70%, (z)=0-60%, all percentages expressed in terms of w/w, the process comprising polymerising a mixture of the hydrophobic and basic monomer or a mixture of the hydrophobic, hydrophilic and basic monomer.
Dependencies are inferred from the claim text.