Closed loop automated matrix removal

An apparatus, comprising:

• a sample extraction module operable to extract sample from a selected one of a plurality of process solution baths;
• at least one dilution and spiking module operable to spike and dilute extracted sample to form a processed solution;
• a source of reagent solution reactive with a matrix in the processed solution to form a precipitate;
• a plurality of matrix removal modules, each matrix removal module operable in a mixing cycle to mix the processed solution with the reagent solution to form a reaction mixture having the precipitate and to filter the precipitate from the reaction mixture through a filter to form a filtered solution, each matrix removal module operable in a flushing cycle to flush the filter;
• and
• a control system to control the mixing and flushing cycles of the plurality of matrix removal modules such that as one matrix removal module is in the mixing cycle another matrix removal module is in the flushing cycle.

An apparatus for the automated removal of a matrix from a solution containing an analyte of interest, comprising:

• at least one analytical instrument operable to periodically measure a concentration of the matrix;
• a source of reagent, the reagent being reactive with the matrix to neutralize the matrix;
• and
• a reaction vessel, wherein the apparatus has a neutralizing configuration in which a volume of the solution and a volume of the reagent react in the reaction to form a neutralized mixture, the volume of the reagent being based upon a most-recent matrix concentration measurement by the analytical instrument.