Method for making a pharmaceutically active ingredient abuse-prevention device

A method of making a pharmaceutically active ingredient abuse-prevention device, the method comprising:

• providing a pharmaceutically active ingredient;
• providing an antagonist of the pharmaceutically active ingredient, the antagonist being in selective fluid communication with the pharmaceutically active ingredient;
• and
• configuring electronic circuitry to selectively operate the fluid communication so as to, upon recognition of at least one predetermined fault condition, mix the pharmaceutically active ingredient with the antagonist, thereby rendering the pharmaceutically active ingredient substantially ineffective.

A system for preventing pharmaceutically active ingredient abuse, comprising:

• a reservoir containing a pharmaceutically active ingredient;
• a chamber containing an antagonist of the pharmaceutically active ingredient, the chamber selectively fluidly coupled to the reservoir;
• and
• electronic circuitry operatively controlling the fluid coupling;
• wherein in response to obtaining information indicative of at least one predetermined fault condition, the electronic circuitry renders the reservoir in fluid communication with the chamber such that the antagonist is mixed with the pharmaceutically active ingredient, thereby rendering the pharmaceutically active ingredient substantially ineffective.

An inhaler, comprising:

• at least one drop generating member;
• a first reservoir in fluid communication with the at least one drop generating member, the first reservoir containing a pharmaceutically active ingredient;
• a second reservoir in selective fluid communication with the at least one drop generating member, the second reservoir containing an antagonist to the pharmaceutically active ingredient;
• and
• a controller configured to receive information indicative of at least one predetermined fault condition, the controller in electronic communication with, and operatively controlling the at least one drop generating member and the selective fluid communication of the second reservoir;
• wherein upon receiving information indicative of the at least one predetermined fault condition, the controller generates signals to place the second reservoir in fluid communication with the at least one drop generating member, thereby releasing the antagonist at substantially the same time as the pharmaceutically active ingredient, thereby rendering the pharmaceutically active ingredient substantially ineffective.

A method of making a pharmaceutically active ingredient abuse-prevention device, the method comprising:

• providing a pharmaceutically active ingredient;
• providing an antagonist of the pharmaceutically active ingredient, the antagonist being in selective fluid communication with the pharmaceutically active ingredient;
• and
• configuring a mechanical member to selectively operate the fluid communication so as to, upon recognition of at least one predetermined fault condition, mix the pharmaceutically active ingredient with the antagonist, thereby rendering the pharmaceutically active ingredient substantially ineffective.

An inhaler for delivering bioactive compositions, the inhaler comprising:

• at least one drop generating member;
• a first reservoir in fluid communication with the at least one drop generating member, the first reservoir containing a pharmaceutically active ingredient;
• a second reservoir containing an antagonist to the pharmaceutically active ingredient, the second reservoir in selective fluid communication with the first reservoir;
• and
• a controller responsive to at least one predetermined fault condition, the controller in electronic communication with, and operatively controlling the at least one drop generating member;
• wherein in response to the at least one predetermined fault condition, the controller generates signals to place the first reservoir in fluid communication with the second reservoir, thereby mixing the pharmaceutically active ingredient with the antagonist, thereby rendering the pharmaceutically active ingredient substantially ineffective.

An inhaler, comprising:

• a drop ejector;
• a reservoir in fluid communication with the drop ejector, the reservoir adapted to contain a pharmaceutically active ingredient;
• a chamber adapted to contain an antagonist of the pharmaceutically active ingredient, the chamber selectively fluidly coupled to the reservoir;
• and
• electronic circuitry operatively controlling the drop ejector and the fluid coupling of the chamber to the reservoir;
• wherein in response to at least one predetermined fault condition, the electronic circuitry renders the reservoir in fluid communication with the chamber such that the antagonist is adapted to be mixed with the pharmaceutically active ingredient, thereby rendering the pharmaceutically active ingredient substantially ineffective.