Powder formation by atmospheric spray-freeze drying
OwnerZhaolin Wang, Warren Finlayinventors
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Abstract
A method of manufacturing heat-sensitive pharmaceutical powder is disclosed. The original pharmaceutical substances are dissolved in a solution or suspended in a suspension, which is sprayed through an atomizing nozzle and frozen in a cold gas phase or liquid nitrogen atomized directly in the spray-freeze chamber or gas jacket at the same time (for cooling purposes). The particles are freeze-dried at roughly atmospheric pressure in a down-stream fluid flow with exit filter thereby to remove moisture entrapped on or inside the frozen particles. The system has applicability for forming other powders.
Claims15
A method of creating a powder, comprising the steps of:
- spraying a carrier liquid containing a powder forming ingredient to form a flow of liquid droplets;
- entraining the flow of liquid droplets within a concurrent flow of coolant for sufficient time to freeze the liquid droplets into frozen particles;
- and
- drying the frozen particles to form a dry powder.
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Dependencies are inferred from the claim text.