Aerosol preparation comprising sealed container and enclosed therein aerosol composition containing marcolide compound

Abstract

An aerosol preparation comprising an enclosure enclosing an aerosol composition containing a macrolide compound (e.g., tacrolimus) serving as an active ingredient has a problem such that the formulation of the aerosol composition is changed with the passage of time so as to reduce the ratio of the active ingredient in the aerosol composition because the macrolide compound as the active ingredient is partly adsorbed to a “gasket” of a valve part made of resinous material. In an aerosol preparation of the invention comprising an aerosol composition containing a macrolide compound and an enclosure enclosing the aerosol composition, a valve part of the enclosure has a “gasket” made of at least one resinous material selected from butyl rubber, ethylene-propylene rubber, chloroprene rubber, polyethylene, polybutylene terephthalate, polyacetal, polyamide, polytetrafluoroethylene, polypropylene and thermoplastic elastomer, thereby solving the problem.

Dependencies are inferred from the claim text.