Control and monitoring of non-resonant radiation-induced nucleation, crystallization, and polymorph formation
OwnerDavid Tuschel, Arjun Bangaloreinventors
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Abstract
The invention relates to methods of assessing the polymorphic form of a substance by assessing Raman-shifted radiation scattered by a particle of the substance. The method is useful, for example, for assessing particle sizes and size distributions in mixtures containing both particles of the substance and other materials. The invention also relates to methods of selecting and controlling polymorph formation by illuminating a material with non-resonant (i.e., non-absorbed) laser radiation as it is thermally driven through a phase transition temperature.
Claims27
A method of generating a selected polymorph of a compound, the method comprising irradiating the compound using non-resonant radiation as the compound is thermally driven through a phase transition.
A method of assessing the polymorphic form of a substance in a microscopic field, the method comprising irradiating the substance, assessing Raman-shifted radiation scattered from the substance, and correlating the Raman-shifted radiation with the polymorphic form of the substance.
19-49. (canceled)
A method of assessing the polymorphic form of a substance in a microscopic field, the method comprising identifying a portion of the field that contains the substance, irradiating the portion, assessing Raman-shifted radiation scattered from the portion, and correlating the Raman-shifted radiation with the polymorphic form of the substance.
51-54. (canceled)
A method of assessing the polymorphic form of a crystalline substance in a sample in a microscopic field, the method comprising irradiating the sample, assessing Raman-shifted radiation scattered from the sample, and correlating the Raman-shifted radiation with the polymorphic form or forms of the substance.
56-61. (canceled)
A device for generating a selected polymorph of a compound, the device comprising a temperature controller for thermally driving the compound through a phase transition and a radiation source for irradiating the compound with non-resonant radiation as the compound is thermally driven through the phase transition.
Dependencies are inferred from the claim text.