DNA vaccines for farm animals, in particular bovines and porcines
AssigneeMerial Limited
InventorsJean-Christophe Audonnet, Laurent Fischer, Simona Barzu-Le-Roux
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Abstract
DNA vaccine against a pathogen affecting farm animals, in particular bovines or porcines, comprising a plasmid containing a nucleotide sequence encoding an immunogen of a pathogen of the animal species considered, under conditions allowing the in vivo expression of this sequence, and a cationic lipid containing a quaternary ammonium salt, of formula in which R1 is a saturated or unsaturated linear aliphatic radical having 12 to 18 carbon atoms, R2 is another aliphatic radical containing 2 or 3 carbon atoms, and X a hydroxyl or amine group, this lipid being preferably DMRIE.
Claims39
1-83. (canceled)
A DNA vaccine against a porcine pathogen, wherein the porcine pathogen is porcine herpesvirus or Aujeszky's disease (pseudorabies virus or PRV), porcine reproductive respiratory syndrome virus (or PRRSV), swine influenza virus (or SIV), conventional hog cholera virus (or HCV) or a parvovirus in porcines, comprising at least one plasmid that contains and expresses in a porcine host cell a nucleotide sequence encoding an immunogen of the porcine pathogen, and a cationic lipid containing a quaternary ammonium salt, of the formula
- in which R1 is a saturated or unsaturated linear aliphatic radical having 12 to 18 carbon atoms, R2 is an aliphatic radical containing 2 or 3 carbon atoms, and X a hydroxyl or amine group.
Dependencies are inferred from the claim text.