Pro-fibrotic coatings
AssigneeSurModics, Inc.
InventorsJoseph Chinn, Stephen Chudzik, Sean Stucke
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Abstract
Pro-fibrotic coatings for medical articles are described that include a pro-fibrotic polymer such as collagen. The pro-fibrotic coatings can also include a thromboresistant polymer. The coatings can be formed by activation of photoreactive groups pendent or independent of the coating materials.
Claims21
An implantable medical article comprising a pro-fibrotic coating, the pro-fibrotic coating comprising (a) collagen, (b) thromboresistant agent, and (c) a photoreactive group.
A method for forming a pro-fibrotic coating on a medical article comprising the steps of:
- (a) disposing a first composition comprising a thromboresistant agent,
- (b) disposing a second composition comprising collagen,
- wherein photoreactive groups are present in the first coating composition, second coating composition, independent of the first and second coating composition, or combinations thereof, and
- (c) activating the photoreactive groups to form the pro-fibrotic coating.
A method for forming a pro-fibrotic coating on a medical article comprising the steps of:
- (a) disposing a composition comprising a collagen and a thromboresitant agent, wherein photoreactive groups are present in the first coating composition, second coating composition, independent of the first and second coating composition, or combinations thereof, and
- (b) activating the photoreactive groups to form the pro-fibrotic coating.
A method for forming a pro-fibrotic coating on a medical article comprising the steps of:
- (a) disposing a first composition comprising a thromboresitant polymer comprising polymerizable groups,
- (b) disposing a second composition comprising collagen comprising polymerizable groups,
- wherein a polymerization initiator is present in the first coating composition, second coating composition, independent of the first and second coating composition, or combinations thereof, and
- (c) activating the polymerization initiator to form the pro-fibrotic coating.
Dependencies are inferred from the claim text.