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US 2006/0079700 A1Published application
Method for the preparation of citalopram
AssigneeH. Lundbeck A/S
InventorsHans Petersen, Michael Rock
Life of this patent
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Abstract
The invention provides a new and improved method for the preparation of 5-cyano-phtalid, which is a key intermediate in the preparation of the antidepressant compound citalopram.
Claims16
A process for the preparation of a compound of the formula
- comprising reacting an isobenzofuran-1-one of the formula
- wherein R′ is a halogen or CF3—(CF2)n—SO2—, wherein n is 0-7, with a cyanide source optionally in the presence of a catalyst.
Dependencies are inferred from the claim text.