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US 2006/0079693 A1Published application
Method and intermediate for preparing a prostaglandin F-type compound
AssigneeEverlight USA, Inc.
InventorsRung-Tian Suen, Yu-Liang Liu
Life of this patent
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Abstract
A method for preparing a prostaglandin F-type compound. Also disclosed is an intermediate of the following formula (II) compound wherein R′, X and A have the same meaning as given in the specification.
Claims34
A method for preparing the following formula (I):
- wherein
- R is hydrogen or C1-C5 alkyl;
- X is C1-C6 alkyl, thiazol, imidazole, pyrrolidine, thiophene, oxazole or a phenyl group with 0 to 3 substituted groups, wherein said substituted groups are selected from the groups consisting of C1-C5 alkyl, C1-C4 alkoxy, trifluoromethyl group, C1-C3 aliphatic acylamino group, nitro group, halogen atom, and phenyl group;
- which comprising:
- Using a compound of the following formula (II),
- wherein
- X is defined the same as above formula (I);
- R′ is an aryl group with 0 to 3 substituted groups, wherein said substituted groups are selected from the groups consisting of halogen atom, C1-C6 alkyl, or C6-C10 aryl group;
- A is C═O or C—OH;
- is a triple bond or a double bond in the cis or trans configuration.
7 more elements
A compound of the following formula (II)
- wherein
- X is C1-C6 alkyl, thiazol, imidazole, pyrrolidine, thiophene, oxazole or a phenyl group with 0 to 3 substituted groups, wherein said substituted groups are selected from the groups consisting of C1-C5 alkyl, C1-C4 alkoxy, trifluoromethyl group, C1-C3 aliphatic acylamino group, nitro group, halogen atom, and phenyl group;
- R′ is a aryl group with 0 to 3 substituted groups, wherein said substituted groups are selected from the groups consisting of halogen atom, C1-C6 alkyl, or C6-C10 aryl group;
- A is C═O or C—OH;
- is a triple bond or a double bond in the cis or trans configuration.
2 more elements
A compound of the following formula (S)-(II-c) compound:
- wherein
- X is C1-C6 alkyl, thiazol, imidazole, pyrrolidine, thiophene, oxazole, or a phenyl group with 0 to 3 substituted groups, wherein said substituted groups are selected from the groups consisting of C1-C5 alkyl, C1-C4 alkoxy, trifluoromethyl group, C1-C3 aliphatic acylamino group, nitro group, halogen atom, and phenyl group;
- is a triple bond or a double bond in the cis or trans configuration.
Dependencies are inferred from the claim text.