Arylthiobenzylpiperidine derivatives

A compound having the structure:

• wherein each X1, X2, X3, X4 and X5 is independently CR1 or N, provided that if one X is N then the remaining X are each CR1;
• wherein each y1, y2, y3 and Y4 is independently CR7 or N, provided that if one Y is N then the remaining Y are each CR7;
• wherein D is
• wherein Z is —N(R5) or —O—;
• wherein each A is independently H or straight chained or branched C1-C4 alkyl;
• wherein B is CH or N;
• wherein each R1 is independently H, straight chained or branched C1-C7 alkyl, straight chained or branched C1-C7 fluoroalkyl, straight chained or branched C1-C7 alkoxy, F, Cl, Br or I;
• wherein R2 is H or straight chained or branched C1-C4 alkyl;
• wherein R3is H or straight chained or branched C1-C4 alkyl;
• or wherein if B is N, then the R2 moiety, B, the R3 moiety and a bond formed between the R2 moiety and the R3 moiety form:
• or wherein if B is CH, then the R2 moiety, B, the R3 moiety and a bond formed between the R2 moiety and the R3 moiety form cyclopropyl, cyclobutyl, cyclopentyl or cyclohexyl;
• wherein R4 is H, straight chained or branched C1-C4 alkyl, straight chained or branched C1-C4 fluoroalkyl or F;
• wherein R5 is H or straight chained or branched C1-C4 alkyl;
• wherein each R6 is independently straight chained or branched C1-C7 alkyl, straight chained or branched C1-C7 fluoroalkyl, straight chained or branched C1-C7 alkoxy, F, Cl, Br or I;
• wherein each R7 is independently H, straight chained or branched C1-C7 alkyl, straight chained or branched C1-C7 fluoroalkyl, straight chained or branched C1-C7 alkoxy, F, Cl, Br or I;
• wherein R8 is H, straight chained or branched C1-C4 alkyl, straight chained or branched C1-C4 fluoroalkyl or F;
• wherein m is an integer from 0 to 4 inclusive;
• wherein n is an integer from 0 to 2 inclusive;
• wherein p is an integer from 0 to 4 inclusive;
• wherein q is an integer from 0 to 3 inclusive;
• wherein r is 1 or 2;
• wherein s is an integer from 0 to 4 inclusive;
• wherein t is an integer from 2 to 4 inclusive;
• wherein v is an integer from 0 to 2 inclusive;
• and
• wherein w is an integer from 1 to 5 inclusive;
• or a pharmaceutically acceptable salt thereof.