Junctional adhesion molecule splice variants
AssigneeEli Lilly and Company
InventorsClifford Babbey, Jacquelyn McEntire
Life of this patent
Estimating the term…
Abstract
This invention provides splice variants of human junctional adhesion molecules (huJAM) and polynucleotides which encode the huJAM splice variants. The invention further provides methods using the molecules of the invention for treating wound healing, cancer, inflammatory disorders, immune system disorders and cardiovascular disorder.
Claims17
An isolated huJAM splice variant polypeptide comprising a polypeptide with a sequence which is at least 99% identical to a sequence selected from the group consisting of:
- a) amino acids 1-323 of SEQ ID NO:
- 2,
- b) amino acids 29-323 of SEQ ID NO:
- 2,
- c) amino acids 1-229 of SEQ ID NO:
- 4,
- d) amino acids 31-229 of SEQ ID NO:
- 4,
- e) amino acids 1-265 of SEQ ID NO:
- 5,
- f) amino acids 31-265 of SEQ ID NO:
- 5,
- g) amino acids 1-242 of SEQ ID NO:
- 5, and
- h) amino acids 31-242 of SEQ ID NO:
- 5.
An isolated polynucleotide encoding a huJAM splice variant polypeptide comprising a sequence which is at least 99% identical to a sequence selected from the group consisting of:
- a) amino acids 1-323 of SEQ ID NO:
- 2,
- b) amino acids 29-323 of SEQ ID NO:
- 2,
- c) amino acids 1-229 of SEQ ID NO:
- 4,
- d) amino acids 31-229 of SEQ ID NO:
- 4,
- e) amino acids 1-265 of SEQ ID NO:
- 5,
- f) amino acids 31-265 of SEQ ID NO:
- 5,
- g) amino acids 1-242 of SEQ ID NO:
- 5, and
- h) amino acids 31-242 of SEQ ID NO:
- 5.
An isolated polynucleotide encoding a huJAM splice variant wherein said polynucleotide is selected from the group consisting of SEQ ID NO:
- 6, SEQ ID NO:
- 7, and SEQ ID NO:
- 8.
Dependencies are inferred from the claim text.