Estrogenic compounds as anti-mitotic agents
AssigneeChildren's Medical Center Corporation
InventorsRobert D'Amato, Moses Folkman
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Abstract
The application discloses methods of treating mammalian diseases characterized by abnormal cell mitosis by administering estradiol derivatives including those comprising colchicine or combretastatin A-4 structural motifs of the general formulae found below in a dosage sufficient to inhibit cell mitosis. The application discloses novel compounds used in the methods.
Claims13
1-25. (canceled)
A composition comprising 2-methoxyestradiol incorporated into a biodegradable polymer.
A method of treating an abnormal stimulation of endothelial cells in a patient comprising administering to the patient with the tumor, an effective amount of 2-methoxyestradiol in a biodegradable polymer.
A method of treating a tumor in a patient comprising administering to the patient with the tumor an effective amount of 2-methoxyestradiol in a biodegradable polymer.
A method of treating inflammation comprising administering to the patient with the tumor, an effective amount of 2-methoxyestradiol in a biodegradable polymer.
Dependencies are inferred from the claim text.