Inhibitors of monomine uptake

A compound of formula I

• wherein
• n is 1, 2 or 3;
• R1 is C2-C10alkyl, C2-C10alkenyl, C3-C8cycloalkyl or C4-C10cycloalkylalkyl, wherein one C—C bond within any cycloalkyl moiety is optionally substituted by an O—C, S—C or C═C bond and wherein each group is optionally substituted with from 1 to 7 halogen substituents and/or with from 1 to 3 substituents each independently selected from hydroxy, cyano, C1-C4alkyl, C1-C4alkylthio (optionally substituted with from 1 to 3 halogen atoms) and C1-C4alkoxy (optionally substituted with from 1 to 3 halogen atoms);
• R2 is H, C1-C4alkyl (optionally substituted with from 1 to 7 halogen atoms), C1-C4alkyl-S(O)x— wherein x is 0, 1 or 2 (optionally substituted with from 1 to 7 halogen atoms), C1-C4alkoxy (optionally substituted with from 1 to 7 halogen atoms), cyano, halogen, phenyl (optionally substituted with from 1 to 3 substituents each independently selected from halogen, C1-C4alkyl and C1-C4alkoxy), phenoxy (optionally substituted with from 1 to 3 substituents each independently selected from halogen, C1-C4alkyl and C1-C4alkoxy) or —CO2(C1-C4alkyl), or together with R3 forms a further benzene ring (optionally substituted with from 1 to 3 substituents each independently selected from halogen, C1-C4alkyl and C1-C4alkoxy);
• R3 is H, C1-C4alkyl (optionally substituted with from 1 to 7 halogen atoms), C1-C4alkyl-S(O)x— wherein x is 0, 1 or 2 (optionally substituted with from 1 to 7 halogen atoms), C1-C4alkoxy (optionally substituted with from 1 to 7 halogen atoms), cyano, halogen, phenyl (optionally substituted with from 1 to 3 substituents each independently selected from halogen, C1-C4alkyl and C1-C4alkoxy), phenoxy (optionally substituted with from 1 to 3 substituents each independently selected from halogen, C1-C4alkyl and C1-C4alkoxy) or —CO2(C1-C4alkyl), or together with R2 or R4 forms a further benzene ring (optionally substituted with from 1 to 3 substituents each independently selected from halogen, C1-C4alkyl and C1-C4alkoxy);
• R4 is H, C1-C4alkyl (optionally substituted with from 1 to 7 halogen atoms), C1-C4alkyl-S(O)x— wherein x is 0, 1 or 2 (optionally substituted with from 1 to 7 halogen atoms), C1-C4alkoxy (optionally substituted with from 1 to 7 halogen atoms), cyano, halogen, phenyl (optionally substituted with from 1 to 3 substituents each independently selected from halogen, C1-C4alkyl and C1-C4alkoxy), phenoxy (optionally substituted with from 1 to 3 substituents each independently selected from halogen, C1-C4alkyl and C1-C4alkoxy) or —CO2(C1-C4alkyl), or together with R3 forms a further benzene ring (optionally substituted with from 1 to 3 substituents each independently selected from halogen, C1-C4alkyl and C1-C4alkoxy);
• R5 is H, C1-C4alkyl (optionally substituted with from 1 to 7 halogen atoms), C1-C4alkoxy (optionally substituted with from 1 to 7 halogen atoms) or halogen;
• R6 is H, C1-C4alkyl (optionally substituted with from 1 to 7 halogen atoms), C1-C4alkoxy (optionally substituted with from 1 to 7 halogen atoms) or halogen;
• R7 is H or C1-C4alkyl;
• R8 is H or C1-C4alkyl;
• R9 is H, halogen, hydroxy, cyano, C1-C4alkyl or C1-C4alkoxy;
• and
• R10 is H, halogen, hydroxy, cyano, C1-C4alkyl or C1-C4alkoxy;
• or a pharmaceutically acceptable salt thereof,
• with the proviso that the compound N-ethyl-N-benzyl-4-piperidinamine is excluded.