Methods for inhibiting angiogenesis
OwnerDennis Hallahan, Joel Hayflick +1inventors
InventorsDennis Hallahan, Joel Hayflick, Chanchal Sadhu
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Abstract
The invention relates generally to methods for inhibiting angiogenesis. More particularly, methods for inhibiting angiogenesis comprise selectively inhibiting phosphoinositide 3-kinase delta (PI3Kδ) activity in endothelial cells. The methods may comprise administration of one or more cytotoxic therapies including but not limited to radiation, chemotherapeutic agents, photodynamic therapies, radiofrequency ablation, anti-angiogenic agents, and combinations thereof.
Claims47
A method for inhibiting angiogenesis, comprising:
- selectively inhibiting phosphoinositide 3-kinase delta (PI3Kδ) activity in endothelial cells to inhibit angiogenesis.
A method for inhibiting endothelial cell migration, comprising:
- selectively inhibiting phosphoinositide 3-kinase delta (PI3Kδ) activity in endothelial cells to inhibit endothelial cell migration.
A method for inhibiting tumor growth, comprising:
- selectively inhibiting phosphoinositide 3-kinase delta (PI3Kδ) activity in endothelial cells to inhibit tumor growth.
A method for reducing tumor vasculature formation or repair, comprising:
- selectively inhibiting phosphoinositide 3-kinase delta (PI3Kδ) activity in endothelial cells to reduce tumor vasculature formation or repair.
A method for inhibiting endothelial tubule formation, comprising:
- selectively inhibiting phosphoinositide 3-kinase delta (PI3Kδ) activity in endothelial cells to inhibit endothelial tubule formation.
A method for reducing tumor mass, comprising:
- selectively inhibiting phosphoinositide 3-kinase delta (PI3Kδ) activity in endothelial cells to reduce tumor mass.
A method for treating or preventing an indication involving angiogenesis, comprising:
- selectively inhibiting phosphoinositide 3-kinase delta (PI3Kδ) activity in endothelial cells to inhibit angiogenesis in an individual in need thereof.
A method for enhancing apoptosis in endothelial cells, comprising:
- selectively inhibiting phosphoinositide 3-kinase delta (PI3Kδ) activity in endothelial cells to enhance apoptosis in endothelial cells.
A method for increasing the therapeutic index of radiation therapy, comprising:
- administering a combination comprising radiation and an amount of a phosphoinositide 3-kinase delta (PI3Kδ) selective inhibitor effective to increase the therapeutic index of the radiation.
A method for increasing the therapeutic index of a chemotherapeutic agent, comprising:
- administering a combination comprising a chemotherapeutic agent and an amount of a phosphoinositide 3-kinase delta (PI3Kδ) selective inhibitor effective to increase the therapeutic index of the chemotherapeutic agent.
A method for increasing the therapeutic index of an anti-angiogenic agent, comprising:
- administering a combination comprising an anti-angiogenic agent and an amount of a phosphoinositide 3-kinase delta (PI3Kδ) selective inhibitor effective to increase the therapeutic index of the anti-angiogenic agent.
A method for reducing highly vascularized tissues, comprising:
- selectively inhibiting phosphoinositide 3-kinase delta (PI3Kδ) activity in endothelial cells to reduce vascular growth or vascular repair of a highly vascularized tissue.
Use of a composition comprising at least one phosphoinositide 3-kinase delta (PI3Kδ) selective inhibitor in the manufacture of a medicament for treating or preventing an indication involving angiogenesis.
Dependencies are inferred from the claim text.