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US 2006/0079534 A1Published application
Cell division inhibitor and a production method thereof
OwnerHiroshi Kanzaki, Kaneo Kanoh +3inventors
InventorsHiroshi Kanzaki, Kaneo Kanoh, Satohiro Yanagisawa, Teruhiko Nitoda, Kazumi Akazawa
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Abstract
The present invention relates to a cell division inhibitor comprising various dehydrodiketopiperazines such as dehydrophenylahistin, or analogs thereof as an active ingredient, and a dehydrogenase and a method for producing the same inhibitor.
Claims15
1-14. (canceled)
A compound of formula (I) or pharmaceutically acceptable salt thereof:
- wherein:
- each of X1 and X2 is independently oxygen or sulfur;
- Y3 is oxygen, sulfur, —NR3—, or —CR31R32—;
- Y4 is oxygen, sulfur, —NR4—, or —CR41R42—;
- R10 is an aryl or aralkyl and is optionally substituted with other substituent(s) and optionally comprises one or more heteroatoms;
- R20 is an aryl or aralkyl and is optionally substituted with other substituent(s) and optionally comprises one or more heteroatoms, with the proviso that R20 does not include a phenyl group;
- each of R3 and R4 is independently selected from the group consisting of hydrogen, halogen, C1-25 alkyl, C2-25 alkenyl, C2-25 alkynyl, C1-25 alkoxy, aralkyl, hydroxyl, amino, nitro, and aryl, each of which is optionally substituted with other substituent(s), wherein any part of a carbon chain in R3 and R4 may be branched or cyclized, and may comprise one or more heteroatoms;
- each of R31, R32, R41, and R42 is independently selected from the group consisting of hydrogen, halogen, C1-25 alkyl, C2-25 alkenyl, C2-25 alkynyl, C1-25 alkoxy, aralkyl, hydroxyl, amino, nitro, and aryl, each of which is optionally substituted with other substituent(s), wherein any part of a carbon chain in R31, R32, R41, and R42 may be branched or cyclized, and may comprise one or more heteroatoms;
- R10 and any of R3, R31, or R32 may together from a ring;
- R20 and any of R4, R41, or R42 may together from a ring;
- each bond depicted by a solid line and dashed line represents a carbon-carbon single bond or a carbon-carbon double bond with E or Z configurations;
- and
- at least one of said groups may have a protecting group capable of decomposing in vivo;
- with the proviso that the compound of formula I does not include the compound having the following structure:
11 more elements
Dependencies are inferred from the claim text.