Sulfonamide peri-substituted bicyclics for occlusive artery disease

A compound of formula:

• wherein
• A and B represent a pair of fused 5-, 6- or 7-membered rings, said fused A/B ring system containing from zero to four heteroatoms chosen from nitrogen, oxygen and sulfur and said rings additionally substituted with from zero to four substituents chosen independently from halogen, —OH, loweralkyl, —O-loweralkyl, fluoroloweralkyl, —O-lowerfluoroalkyl, methylenedioxy, ethylenedioxy, alkoxy-loweralkyl, hydroxyloweralkyl, oxo, oxide, —CN, nitro, —S-loweralkyl, amino, loweralkylamino, diloweralkylamino, diloweralkylaminoalkyl, carboxy, carboalkoxy, orthoester, acyl, acylalkyl, carboxamido, loweralkylsulfoxide, loweralkylsulfone, acylamino, phenyl, benzyl, spirothiazolidinyl, phenoxy and benzyloxy;
• a and b represent points of attachment of residues Y and W respectively and a and b are in a peri relationship to one another on said fused A/B ring system;
• d and e represent points of fusion between ring A and ring B in said fused A/B ring system;
• W and Y are linkers comprising from zero to 8 atoms in a chain;
• M is chosen from aryl, substituted aryl, heterocyclyl, substituted heterocyclyl, C6 to C20 alkyl and substituted C6 to C20 alkyl;
• Q is chosen from —N(SO2R1)—, —N(COR1)—, —N(CO2R1)—, —N[PO(O-alkyl)2]—, —NHNR10(SO2R1), and, when W is —CF2— or —CH2CF2—, Q may additionally be —NH—;
• R1 is chosen from aryl, substituted aryl, heteroaryl, substituted heteroaryl, C3-C20 alkyl and fluoroalkyl;
• and
• R10 is chosen from alkyl, aryl and heteroaryl.