Agglomerates by crystallisation
OwnerJohannes Booij, Geertruida Leffertsinventors
Life of this patent
Estimating the term…
Abstract
The present invention describes novel agglomerates in crystalline form of β-lactum compounds, Furthermore, a process for the preparation of said agglomerates, wherein a solution or suspension of at least one β-lactum compound in a solvent is mixed with one or more anti-solvents has been described.
Claims12
An agglomerate of potassium clavulanate crystals, wherein said agglomerate has a loose bulk density between about 0.20 and 0.60 g/mL, a tapped bulk density between about 0.50 and 0.90 g/mL, and a compressibility between about 10 and 40%, wherein said compressibility is calculated as 100 times the ratio of the difference between tapped bulk density and loose bulk density to the tapped bulk density, and said agglomerate has a weight percentage of between 0% and 10% potassium clavulanate crystals in the needle form, with the proviso that the rosette-like crystalline form of potassium clavulanate is excluded.
Dependencies are inferred from the claim text.