Lactose-free, non-hygroscopic and anhydrous pharmaceutical compositions of descarboethoxyloratadine
AssigneeSepracor Inc.
InventorsMartin Redmon, Hal Butler, Stephen Wald, Paul Rubin
Life of this patent
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Abstract
Stable pharmaceutical compositions of descarboethoxyloratadine (DCL), a metabolic derivative of loratadine, for the treatment of allergic rhinitis and other histamine-induced disorders are disclosed. The compositions are formulated to avoid the incompatibility between DCL and reactive excipients such as lactose and other mono- and di-saccharides. Disclosed compositions include lactose-free, non-hygroscopic and anhydrous stable pharmaceutical compositions of DCL.
Claims21
1-40. (canceled)
A pharmaceutical unit dosage form for oral administration, the dosage form comprising a lactose-free core of blended or granulated descarboethoxyloratadine, or a pharmaceutically acceptable salt thereof, and one or more pharmaceutically acceptable inert excipients, wherein the core is coated with an inert coating agent.
A pharmaceutical unit dosage form for oral administration, the dosage form comprising an anhydrous core of blended or granulated descarboethoxyloratadine, or a pharmaceutically acceptable salt thereof, and one or more pharmaceutically acceptable inert excipients, wherein the core is coated with an inert coating agent.
A pharmaceutical unit dosage form for oral administration, the dosage form comprising a substantially non-hygroscopic core of blended or granulated descarboethoxyloratadine, or a pharmaceutically acceptable salt thereof, and one or more pharmaceutically acceptable inert excipients, wherein the core is coated with an inert coating agent.
Dependencies are inferred from the claim text.